State of the art review: HLA matching and outcome of unrelated donor umbilical cord blood transplants.
نویسندگان
چکیده
1 Children’s National Medical Center, Washington, DC; 2 National Marrow Donor Program, Minneapolis, Minnesota; 3 Department of Oncology, Georgetown University, Washington, DC; 4 Memorial Sloan-Kettering Cancer Center, New York, New York; 5 Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio; 6 Europdonor Foundation, Leiden, The Netherlands; 7 Emory University School of Medicine, Atlanta, Georgia; 8 Seattle Cancer Care Alliance, Seattle, Washington; 9 University of New Mexico School of Medicine, Albuquerque, New Mexico; 10 CIBMTR Statistical Center, Medical College of Wisconsin, Milwaukee, Wisconsin; and 11 H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
منابع مشابه
The Predictive Value of HLA-DR Matching and Cytokine Gene Polymorphisms in Renal Allograft Acute Rejection: A Living-unrelated Donor (LURD) Study
Background: In addition to Human Leukocyte Antigens (HLA) compatibility, gene polymorphisms in cytokines might also be important in the quality of allogeneic immune response. Objective: To evaluate the influence of HLA-DR matching and a number of cytokine gene polymorphisms on acute rejection after living-unrelated donor (LURD) kidney transplantation. Methods: A total of 42 renal transplants pe...
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Since the first successful allogeneic transplants performed in Seattle 50 years ago, the field of transplantation has evolved considerably, with improvements in human leukocyte antigen typing, patient selection, reduced intensity regimens, and graft-versus-host disease prophylaxis. A major breakthrough has been the availability of more donor options, first via the National Marrow Donor Program-...
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An analysis of NMDP data shows that allele-level matching for HLA A, B, C, and DRB1 is preferred in the selection of adult unrelated donors. If mismatching is unavoidable, mismatches at HLA B or C may be better tolerated than those at A or DRB1. Whether mismatches are at the allele level (ie, within an antigen group) or at the antigen level makes no difference in outcome, except at HLA C where ...
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Allogeneic hematopoietic cell transplantation has an established role in the treatment of adults with acute lymphoblastic leukemia whose survival when recipients of grafts from adult unrelated donors approaches that of recipients of grafts from sibling donors. Our aim was to determine the role of mismatched unrelated cord blood grafts in transplantation for 802 adults with acute lymphoblastic l...
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Umbilical cord blood is the baby's blood left over in the umbilical cord and placenta after a baby is delivered and the cord is cut. Cord blood has all of the features of regular blood, but it is also a rich source of hematopoietic stem cells. Hematopoietic stem cells are unspecialized cells that produce all blood cells. These include: • Platelets, which are needed for blood clotting • Red...
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عنوان ژورنال:
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
دوره 14 1 شماره
صفحات -
تاریخ انتشار 2008